Emeritus Faculty

Decorative button

Scientists: John H. Weiss, M.D., Ph. D.

Dr. John Weiss


Anatomy & Neurobiology

Decorative Icon Weiss Home Page     Decorative Icon Biography     Decorative Icon Research

Research Focus

Working to understand: Alzheimer's disease, ALS, stroke, epilepsy.

Scientific Focus: In vitro studies of neural signaling pathways of relevance to development, synaptic plasticity and neurodegeneration.


Selected Publications

Yin HZ, Hsu CI, Yu S, Rao SD, Sorkin LS, Weiss JH.
TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp Neurol. 2012 Dec;238(2):93-102.

Yin, H.Z., Nalbandian. A., Hsu, C.I., Li, S., Llewellyn, K.J., Mozaffar, T., Kimonis, V.E. and Weiss, J.H.
Slow Development of ALS-Like Spinal Cord Pathology in Mutant Valosin-Containing Protein (VCP) Gene Knock-in Mice. Cell Death & Disease (2012), in press.

Yin HZ, Weiss JH.
Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures. Brain Res. 2012 Apr 11;1448:153-62. Epub 2012 Feb 9.

Shuttleworth CW, Weiss JH.
Zinc: new clues to diverse roles in brain ischemia. Trends Pharmacol Sci. 2011 Aug;32(8):480-6. Epub 2011 May 27. Review.

Medvedeva YV, Lin B, Shuttleworth CW, Weiss JH.
Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. J Neurosci. 2009 Jan 28;29(4):1105-14.

Yin HZ, Tang DT, Weiss JH.
Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS. Exp Neurol. 2007 Oct;207(2):177-85. Epub 2007 Jul 24.

Rao SD, Banack SA, Cox PA, Weiss JH.
BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Exp Neurol. 2006 Sep;201(1):244-52. Epub 2006 Jun 9.

Weiss, J. H., Kwak, S.,
Ca2+ permeable AMPA channels in neurodegenerative disease and ischemia, Curr. Op. Neurobiol. 16(3):281-7 (2006).

Ogoshi F, Yin HZ, Kuppumbatti Y, Song B, Amindari S, Weiss JH.
Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. Exp Neurol. 2005 Jun;193(2):384-93.

Rao SD, Weiss JH.
Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis. Trends Neurosci. 2004 Jan;27(1):17-23. Review. No abstract available.

Ogoshi F, Weiss JH.
Heterogeneity of Ca2+-permeable AMPA/kainate channel expression in hippocampal pyramidal neurons: fluorescence imaging and immunocytochemical assessment. J Neurosci. 2003 Nov 19;23(33):10521-30.

Sensi, S.L., Ton-That, D., Sullivan, P.G., Jonas, E.A., Gee, K.R., Kaczmarek, L.K. and Weiss, J.H.
Modulation of mitochondrial function by endogenous Zn2+ pools, Proc. Natl. Acad. Sci. (USA) 100, 6157-6162 (2003).

Rao, S.D., Yin, H.Z. and Weiss, J.H. Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons, J. Neurosci. 23, 2627-2633 (2003).

Jia, Y.S., Jeng, J.M., Sensi, S.L. and Weiss, J.H.
Zn2+ currents are mediated by Ca2+-permeable AMPA/kainate channels in cultured hippocampal neurons, J. Physiol. 543.1, 35048 (2002).

Yin, H.Z., Sensi, S.L., Ogoshi, F. and Weiss, J.H.
Blockade of Ca2+ permeable AMPA/kainate channels decreases oxygen glucose deprivation induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons. J. Neurosci. 22, 1273-9 (2002).

Carriedo, S.G., Sensi, S.L., Yin, H.Z. and Weiss, J.H.
AMPA exposures induce mitochondrial Ca2+ overload and ROS generation in spinal motor neurons in vitro. J. Neurosci. 20, 240-250 (2000).

Contact Information








Dep't Neurology,
Gillespie Neuroscience Facility,
University of California,
Irvine, CA 92697-4292

The Lab

Sungoan Ji
Graduate Student

Supporting This Work

Donations to labs may be applied in many ways: from costs for experiments to support for a student's stipend.

Join us in becoming a part of scientific history, by supporting the work of this lab.

Learn more by contacting Pamela Foster, pamela.foster@uci.edu, or by visiting our Get Involved Page, where you can donate online.