Emeritus Faculty

  • Robert Blanks
  • Ralph Bradshaw
  • James Fallon
  • Roland Giolli
  • Leonard Kitzes
  • Charles Ribak
  • John Swett
Decorative button

Scientists: Martin A. Smith, Ph.D.

Dr. Martin Smith

Professor:

Anatomy & Neurobiology

Decorative Icon Smith Home Page     Decorative Icon Biography     Decorative Icon Research

Research Focus

Working to understand: epilepsy, stroke, alzheimers, cognitive disorders, congestive Heart Failure

Scientific Focus: molecular and cell biology of synapse formation, synaptic plasticity and membrane excitability.

Decorative Icon RECENT PUBLICATIONS ON PUBMED

Selected Publications

Burk, K., A. Desoeuvre, C. Boutin, M.A. Smith, S. Kröger, A. Bosio, M-C. Tiveron, H. Cremer
2012. Agrin-signaling is necessary for the integration of newly generated neurons in the adult olfactory bulb. J Neurosci 32, 3759-3764.

Hilgenberg, L. G., B. Pham, M. Ortega, S. Walid, T. Kemmerly, D.K. O'Dowd, and M.A. Smith
2009. Agrin regulation of a3 sodium-potassium ATPase activity modulates cardiac myocyte contraction. J Biol Chem 284, 16956-16965.

Hilgenberg LG, Pham B, Ortega M, Walid S, Kemmerly T, O'Dowd DK, Smith MA.
2009. Agrin regulation of alpha 3 sodium potassium ATPase activity modulates cardiac myocyte contraction. J Biol Chem, 2009 Apr 16. [Epub ahead of print].

Chen, K., A. Neu, A. L. Howard, C. Foldy, J. Echegoyen, L. Hilgenberg, M. Smith, K. Mackie, and I. Soltesz.
2007. Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures. J Neurosci. 27:46-58.

Tan, Z., X. Sun, F. S. Hou, H. W. Oh, L. G. Hilgenberg, E. M. Hol, F. W. van Leeuwen, M. A. Smith, D. K. O'Dowd, and S. S. Schreiber.
2007. Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Cell Death Differ. 14:1721-1732.

Hilgenberg, L.G., Su, H., Gu, H., O'Dowd D. K., and Smith, M.A.
(2006). α3Na+/K+-ATPase is a neuronal receptor for agrin. Cell 125, 359-369.

Hilgenberg, L.G. and M.A. Smith
2004. Agrin signaling in cortical neurons is mediated by a tyrosine kinase-dependent increase in intracellular Ca(2+) that engages both CaMKII and MAPK signal pathways. J. Neurobiol. 61: 289-300.

Hoover, C. L., L. G. W. Hilgenberg, et al.
2003. The COOH-terminal domain of agrin signals via a synaptic receptor in CNS neurons. J. Cell Biol. 161: 923-932.

Hilgenberg, L.G.W., K.D. Ho, D. Lee, D.K. O'Dowd, and M.A. Smith.
2002. Agrin regulates neuronal responses to excitatory neurotransmitters in vitro and in vivo. Mol. Cell. Neurosci. 19:97-110.

Contact Information

E-mail:

masmith@uci.edu

Phone:

949-824-7079,
949-824-3463

FAX:

949-824-1105

Address:

Dep't Anatomy & Neurobiology,
School of Medicine,
University of California,
Irvine, CA 92697-1280

The Lab

Ryan Schutte
Postdoctoral Researcher
Ruomo
Associate Scientist

Supporting This Work

Donations to labs may be applied in many ways: from costs for experiments to support for a student's stipend.

Join us in becoming a part of scientific history, by supporting the work of this lab.

Learn more by contacting Sara Johnson, sara.johnson@uci.edu, or by visiting our Get Involved Page, where you can donate online.