Emeritus Faculty

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Scientists: Steven S. Schreiber, M.D.

Dr. Steven S. Schreiber


Anatomy & Neurobiology

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Research Focus

Working to understand: Alzheimer's disease, Parkinson's disease.

Scientific Focus: to elucidate the molecular mechanisms underlying selective neuronal degeneration, a major pathological feature of Alzheimer’s, Parkinson’s and other age-related neurodegenerative diseases. We employ state-of-the-art molecular, biochemical, immunohistochemical and histological techniques in animal and cell culture studies.


Selected Publications

Marquez-Lona EM, Tan Z, Schreiber SS.
Nucleolar stress characterized by downregulation of nucleophosmin: a novel cause of neuronal degeneration. Biochem Biophys Res Commun. 417: 514-520, 2012.

Green, K.N. and Schreiber, S.S.
Advances in our understanding of the pathophysiology of Alzheimer's disease. US Neurology, 6: 22–31, 2010.

Liu, B., Rasool, S., Yang, Z., Glabe, C.G., Schreiber, S.S., Ge, J. and Tan, Z.
Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice. Am. J. Pathol. 175: 2099-2110, 2009.

Tan, Z., Shi, L. and Schreiber, S.S.
Differential Expression of redox factor-1 associated with beta-amyloid-mediated neurotoxicity. Open Neurosci. J. 3: 26-34, 2009.

Tan, Z. and Schreiber, S.S.
Tumor suppressor p53: a multifunctional protein implicated in seizure-induced neuronal cell death. In Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms, ed. Fujikawa, D.G., Springer Life Sciences, Heidelberg, 2009.

Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM.
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci. 2008 Nov 5;28(45):11500-10.

Tan Z, Sun X, Hou FS, Oh HW, Hilgenberg LG, Hol EM, van Leeuwen FW, Smith MA, O'Dowd DK, Schreiber SS.
Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Cell Death Differ. 2007 Oct;14(10):1721-32. Epub 2007 Jun 15.

Quach N, Chan T, Lu TA, Schreiber SS, Tan Z.
Induction of DNA repair proteins, Ref-1 and XRCC1, in adult rat brain following kainic acid-induced seizures. Brain Res. 2005 May 3;1042(2):236-40.

Contact Information








Department of Neurology,
106 Irvine Hall,
University of California,
Irvine, CA 92697-4275

Supporting This Work

Donations to labs may be applied in many ways: from costs for experiments to support for a student's stipend.

Join us in becoming a part of scientific history, by supporting the work of this lab.

Learn more by contacting Pamela Foster, pamela.foster@uci.edu, or by visiting our Get Involved Page, where you can donate online.