Emeritus Faculty

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Scientists: Richard T. Robertson, Ph.D.

Dr. Richard T. Robertson


Anatomy & Neurobiology
School of Biological Sciences
Chao Comprehensive Cancer Center

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Research Focus

Working to Understand:
cell surface molecules that identify certain classes of cells.

       Scientific Foci, Cancer: use of peptide-containing liposomes and immuno-liposomes to identify cell surface molecules of tumor cells for delivery of chemotherapeutic drugs specifically to targeted cancer cells.

       Scientific Foci, Neuroscience: studies of expression of cell-secreted neurotrophins that aid axonal target selection in developing cerebral cortex, including both neocortex and hippocampal formation. Experiments use tissue slice and dissociated cell culture techniques to understand how expression of neurotrophin-3 guides cholinergic axons to form synapses with cortical neurons.


Selected Publications

   List 1: Cancer Drug Delivery
   List 2:

1: Cancer Drug Delivery

Development, differentiation, and vascular components of subcutaneous and intrahepatic Hepa129 tumors in a mouse model of hepatocellular carcinoma.
Robertson RT. Gutierrez P. M., Baratta, J.L., Thordarson, K., Braslow, J., Haynes, S.M. and Longmuir, K.J., Histology and Histopathology 2016; 31: 403-413

Use of labeled tomato lectin for imaging vasculature structures.
Robertson RT. Levine ST, Haynes SM, Gutierrez P, Baratta JL, Tan Z, Longmuir KJ., Histochem Cell Biol. 2015 Feb;143(2):225-34. doi: 10.1007/s00418-014-1301-3. Epub 2014 Dec 23.

Characterization of Kupffer cells in livers of developing mice.
Lopez BG, Tsai MS, Baratta JL, Longmuir KJ, Robertson RT. Comp Hepatol. 2011 Jul 12;10(1):2.

Binding patterns of peptide-containing liposomes in liver and spleen of developing mice: comparison with heparan sulfate immunoreactivity.
Tsai MS, Baratta JL, Longmuir KJ, Robertson RT.
J Drug Target. 2011 Aug;19(7):506-15. Epub 2010 Aug 24.

Liposomal delivery of doxorubicin to hepatocytes in vivo by targeting heparan sulfate.
Longmuir KJ, Haynes SM, Baratta JL, Kasabwalla N, Robertson RT.
Int J Pharm. 2009 Dec 1;382(1-2):222-33. Epub 2009 Aug 5.

Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis.
Baratta JL, Ngo A, Lopez B, Kasabwalla N, Longmuir KJ, Robertson RT.
Histochem Cell Biol. 2009 Jun;131(6)Ω:713-26. Epub 2009 Mar 3.

Liposomes incorporating a Plasmodium amino acid sequence target heparan sulfate binding sites in liver.
Robertson RT, Baratta JL, Haynes SM, Longmuir KJ.
J Pharm Sci. 2008 Aug;97(8):3257-73.

Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence.
Longmuir KJ, Robertson RT, Haynes SM, Baratta JL, Waring AJ.
Pharm Res. 2006 Apr;23(4):759-69. Epub 2006 Mar 24.

1: Neuroscience

Neurotrophic factors rescue basal forebrain cholinergic neurons and improve performance on a spatial learning test.
Lee YS, Danandeh A, Baratta J, Lin CY, Yu J, Robertson RT
Exp Neurol. 2013 Nov;249:178-86.

Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum.
Robertson RT, Baratta J, Yu J, LaFerla FM.
Neuroscience. 2009 Dec 15;164(3):1334-46. Epub 2009 Sep 20.

A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex.
Robertson RT, Baratta J, Yu J, Guthrie KM.
Neuroscience. 2006 Dec 1;143(2):523-39. Epub 2006 Oct 13.

Re-growth of catecholaminergic fibers and protection of cholinergic spinal cord neurons in spinal repaired rats.
Lee YS, Lin CY, Robertson RT, Yu J, Deng X, Hsiao I, Lin VW. Eur J Neurosci. 2006 Feb;23(3):693-702.

Patterns of afferent projections to the dentate gyrus studied in organotypic co-cultures.
Guthrie KM, Tran A, Baratta J, Yu J, Robertson RT.
Brain Res Dev Brain Res. 2005 Jun 30;157(2):162-71.

Contact Information








Dep't Anatomy & Neurobiology, School of Medicine,
University of California,
Irvine, CA 92697-1280

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