Emeritus Faculty

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Scientist: Daniele Piomelli, Ph.D

Dr. Daniele Piomelli

Professor:

Anatomy & Neurobiology
Biological Chemistry
Pharmacology

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Research

Working to understand: inflammation, obesity, pain, autism and drug addiction

Scientific Focus: functions of lipid-derived signaling molecules in physiological and pathological regulation

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Selected Publications

D. Pizzirani, A. Bach, N. Realini, A. Armirotti, L. Mengatto, I. Bauer, S. Girotto, C. Pagliuca, M. De Vivo, M. Summa, A. Ribeiro and D. Piomelli
2014. Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase. Angew Chem Int Ed Engl., in the press. PMID: 25395373

D. Piomelli and O. Sasso
2014. Peripheral gating of pain signals by endogenous lipid mediators. Nat Neurosci 17, 164-174. PMCID:PMC4020413

O. Sasso, G. Moreno-Sanz, C. Martucci, N. Realini, M. Dionisi, L. Mengatto, A. Duranti, G. Tarozzo, G. Tarzia, M. Mor, R. Bertorelli, A. Reggiani and D. Piomelli
2013. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain 154, 350-360. PMCID: PMC3723234

K.M. Jung, M. Sepers, C.M. Hemstridge, O. Lassalle, D. Neuhofer, H. Martin, M. Ginger, A. Frick, N.V. DiPatrizio, K. Mackie, I. Katona, D. Piomelli and O.J. Manzoni
2012. Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nat Commun 3, 1080. PMCID: PMC3657999

Jung KM, Clapper JR, Fu J, D'Agostino G, Guijarro A, Thongkham D, Avanesian A, Astarita G, DiPatrizio NV, Frontini A, Cinti S, Diano S, Piomelli D.
2012. 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. Cell Metab. Mar 7;15(3):299-310.

DiPatrizio NV, Astarita G, Schwartz G, Li X, Piomelli D.
2011. Endocannabinoid signal in the gut controls dietary fat intake. Proc Natl Acad Sci U S A. Aug 2;1 08(31):12904-8. Epub 2011 Jul 5.

Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, SanchinI S, Sciolino NR, Spradley JM, Hohmann AG, Calignano A, Mor M, Tarzia G and Piomelli D.
2010. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nature Neuroscience 13, 1265-1270.

Solorzano C, Zhu C, Battista N, Astarita G, Lodola A, Rivara S, Mor M, Russo R, Maccarrone M, Antonietti F, Duranti A, Tontini A, Cuzzocrea S, Tarzia G and Piomelli D.
2009. Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. Proc Natl Acad Sci U S A, 106, 20966-20971.

Schwartz GJ, Fu J, Astarita G, Li X, Gaetani S, Campolongo P, Cuomo V and Piomelli D.
2008. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab 8, 281-288.

Piomelli D, Astarita G and Rapaka R.
2007. A neuroscientist’s guide to lipidomics. Nat Rev Neurosci, 8, 743-754.

Hohmann AG, Suplita II RL, Bolton NM, Neely MH, Fegley D, Mangieri R, Krey J, Walker JM, Holmes PV, Crystal JD, Duranti A, Tontini A, Mor M, Tarzia G, and Piomelli D.
2005. An endocannabinoid mechanism for stress-induced analgesia. Nature 435, 1108-1112.

Fegley D, Kathuria S, Mercier R, Li C, Goutopoulos A, Makriyannis A and Piomelli D.
2004. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc Natl Acad Sci U S A 101, 8756-8761.

Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodríguez de Fonseca F, Rosengarth A, Luecke H, Di Giacomo B, Tarzia G and PiomellI D.
2003. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425, 90-93.

Rodriguez de Fonseca F, Navarro M, Gomez R, Escuredo L, Nava F, Fu J, Murillo-Rodriguez E, Giuffrida A, LoVerme J, Gaetani S, Kathuria S, Gall C, and Piomelli D.
2001. An anorexic lipid mediator regulated by feeding. Nature 414, 209-212.

Contact Information

E-mail:

piomelli@uci.edu

Phone:

949-824-7080

FAX:

949-824-6305

Address:

Anatomy & Neurobiology,
3101 Gillespie NRF,
University of California, Irvine
Irvine, CA 92697-1275

The Lab

Faizy Ahmed, Ph.D.
Project Scientist
Jennifer Daglian, B.S.
Staff Research Associate
Miki Igarashi, Ph.D.
Associate Specialist
Kwang Mook Jung, Ph.D.
Assist. Adjunct Professor
Diane Lee, B.S.
Junior Specialist
James Lim
Graduate Student
Collin Merrill, Ph.D.
Postdoctoral Scholar
Guillermo Moreno Sanz, Ph.D.
Assistant Specialist
Vidya Narayanaswami, Ph.D.
Postdoctoral Scholar
Fariba Oveisi, B.S.
Specialist
Don Wei
Graduate Student

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