Emeritus Faculty

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Scientist: Frances M. Leslie, Ph.D

Dr. Frances Leslie

Professor:

Pharmacology
Anatomy & Neurobiology

Dean:

Graduate Division

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Research Focus

Working to understand: drug addiction

Scientific Focus: development of the nervous system, with a particular focus on the development of neurotransmitter systems and the effects of drugs of abuse on nervous system development.

Decorative Icon RECENT PUBLICATIONS ON PUBMED

Selected Publications

Toll L, Zaveri NT, Polgar WE, Jiang F, Khroyan TV, Zhou W, Xie XS, Stauber GB, Costello MR, Leslie FM.
AT-1001:a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self- administration in rats. Neuropsychopharmacology. 2012 May;37(6):1367-76. doi: 10.1038/npp.2011.322. Epub 2012 Jan 25.

Lotfipour S, Arnold MM, Hogenkamp DJ, Gee KW, Belluzzi JD, Leslie FM.
The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition. Neuropharmacology. 2011 Jul-Aug;61(1-2):95-104. Epub 2011 Mar 23.

Dao JM, McQuown SC, Loughlin SE, Belluzzi JD, Leslie FM.
Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism. Neuropsychopharmacology. 2011 Jun;36(7):1319-31. Epub 2011 Mar 16.

Villégier AS, Belluzzi JD, Leslie FM.
Serotonergic mechanism underlying tranylcypromine enhancement of nicotine self-administration. Synapse. 2011 Jun;65(6):479-89. doi: 10.1002/syn.20864. Epub 2010 Nov 9.

Wei J, Wang J, Dwyer JB, Mangold J, Cao J, Leslie FM, Li MD .
Gestational nicotine treatment modulates cell death/survival-related pathways in the brains of adolescent female rats.
Int J Neuropsychopharmacol. 2010 Apr 29:1-16.

Cao J, Belluzzi JD, Loughlin SE, Dao JM, Chen Y, Leslie FM.
Locomotor and stress responses to nicotine differ in adolescent and adult rats. Pharmacol Biochem Behav. 2010 Apr 25.

Gehricke JG, Potkin SG, Leslie FM, Loughlin SE, Whalen CK, Jamner LD, Mbogori J, Fallon JH.
Nicotine-induced brain metabolism associated with anger provocation. Behav Brain Funct. 2009 Apr 24;5:19.

Cao J, Dwyer JB, Mangold JE, Wang J, Wei J, Leslie FM, Li MD.
Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats. Int J Neuropsychopharmacol. 2010 Mar 3:1-18.

Villégier AS, Gallager B, Heston J, Belluzzi JD, Leslie FM.
Age influences the effects of nicotine and monoamine oxidase inhibition on mood-related behaviors in rats. Psychopharmacology (Berl). 2010 Jan 14.

McQuown SC, Dao JM, Belluzzi JD, Leslie FM.
Age-dependent effects of low-dose nicotine treatment on cocaine-induced behavioral plasticity in rats. Psychopharmacology (Berl). 2009 Nov;207(1):143-52.

Contact Information

E-mail:

fmleslie@uci.edu

Phone:

949-824-6699,
949-824-5437
949-824-6351

FAX:

949-824-4855

Address:

Dept of Pharmacology,
367 Med Surge II,
University of California,
Irvine, California 92697-4625

The Lab

James Belluzzi, Ph.D.
Adjunct Professor
Sandra Loughlin, Ph.D.
Specialist
Celina Mojica, Ph.D.
Postdoctoral Fellow
Matthew Costello,
Graduate Student
Armando Larraga,
Graduate Student, Ph.D.
Menglu Yuan,
Graduate Student

Supporting This Work

Donations to labs may be applied in many ways: from costs for experiments to support for a student's stipend.

Join us in becoming a part of scientific history, by supporting the work of this lab.

Learn more by contacting Pamela Foster, pamela.foster@uci.edu, or by visiting our Get Involved Page, where you can donate online.