Emeritus Faculty

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Scientist: Leif A. Havton, M.D., Ph.D.

Dr. Leif Havton

Professor and Vice Chair of Research:

Anesthesiology & Perioperative Care


Anatomy & Neurobiology

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Research Focus

Working to understand: spinal cord injury and repair, stem cell science

Scientific Focus: translational research, special interests in developing new treatments for cauda equine and conus medullaris forms of spinal cord injuries.


Selected/Recent Publications

Chang HH, Havton LA.
Serotonergic 5-HT(1A) receptor agonist (8-OH-DPAT) ameliorates impaired micturition reflexes in a chronic ventral root avulsion model of incomplete cauda equina/conus medullaris injury. Exp Neurol. 2013 Jan;239:210-7. doi: 10.1016/j.expneurol.2012.10.015. Epub 2012 Oct 23.

Carlstedt T, Havton L.
The longitudinal spinal cord injury: Lessons from intraspinal plexus, cauda equina and medullary conus lesions. Handb Clin Neurol. 2012;109:337-54.

Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski MH.
Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012 Sep 14;150(6):1264-73.

Lu P, Blesch A, Graham L, Wang Y, Samara R, Banos K, Haringer V, Havton L, Weishaupt N, Bennett D, Fouad K, Tuszynski MH.
Motor axonal regeneration after partial and complete spinal cord transection.
J Neurosci. 2012 Jun 13;32(24):8208-18.

Chang HH, Havton LA.
Modulation of the visceromotor reflex by a lumbosacral ventral root avulsion injury and repair in rats. Am J Physiol Renal Physiol. 2012 Sep;303(5):F641-7.

Havton LA.
A lumbosacral ventral root avulsion injury and repair model for studies of neuropathic pain in rats. Methods Mol Biol. 2012;851:185-93.

Wu L, Wu J, Chang HH, Havton LA.
Selective plasticity of primary afferent innervation to the dorsal horn and autonomic nuclei following lumbosacral ventral root avulsion and reimplantation in long term studies. Exp Neurol. 2012 Feb;233(2):758-66. Epub 2011 Dec 8.

Chang HH, Havton LA.
Systemic administration of fluorogold for anatomical pre-labeling of autonomic and motor neurons in the rat spinal cord compromises urodynamic recordings in acute but not long-term studies. Neurourol Urodyn. 2012 Jan;31(1):162-7. doi: 10.1002/nau.21184. Epub 2011 Aug 8.

Zai L, Ferrari C, Dice C, Subbaiah S, Havton LA, Coppola G, Geschwind D, Irwin N, Huebner E, Strittmatter SM, Benowitz LI.
Inosine augments the effects of a Nogo receptor blocker and of environmental enrichment to restore skilled forelimb use after stroke. J Neurosci. 2011 Apr 20;31(16):5977-88.

Ichiyama RM, Broman J, Roy RR, Zhong H, Edgerton VR, Havton LA.
Locomotor training maintains normal inhibitory influence on both alpha- and gamma-motoneurons after neonatal spinal cord transection. J Neurosci. 2011 Jan 5;31(1):26-33.

Contact Information








Gillespie Neuroscience Research Facility, # 2121
837 Health Science Road
University of California,
Irvine, California 92697

The Lab

Huiyi Harriet Chang, Ph.D.
Postdoctoral Researcher
Arthi Amin, Ph.D.
Postdoctoral Researcher

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