Emeritus Faculty

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Scientist: Lisa A. Flanagan, Ph.D.

Dr. Flanagan

Assistant Professor:

Neurology
Anatomy & Neurobiology

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Research Focus

Working to understand: how neural stem cells of the brain and spinal cord become 1 of 3 cell types of the central nervous system: neurons, astrocytes, or oligodendrocytes. Understanding this process will lead to greater control over the final differentiated types of transplanted stem cells

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Selected Publications

Prieto, J.L., J. Lu, J.L. Nourse, L.A. Flanagan, A.P. Lee.
Frequency discretization in dielectrophoretic assisted cell sorting arrays to isolate neural cells. Lab on a Chip, 12(12): 2182-2189, 2012.

Stringari C, Nourse JL, Flanagan LA, Gratton E.
Phasor fluorescence lifetime microscopy of free and protein-bound NADH reveals neural stem cell differentiation potential. PLoS One. 2012;7(11):e48014. doi: 10.1371/journal.pone.0048014. Epub 2012 Nov 5.

Lu, J., C.C. Barrios, A.R. Dickson, J.L. Nourse, A.P. Lee, L.A. Flanagan.
Advancing practical usage of microtechnology: a study of the functional consequences of dielectrophoresis on neural stem cells. Integrative Biology 4(10): 1223-36, 2012.

Sharp, K.G., A.R. Dickson, S.A. Marchenko, K.M. Yee, P.N. Emery, I. Laidmäe, R. Uibo, E.S. Sawyer, O. Steward, L.A. Flanagan.
Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation. Experimental Neurology 235(1): 345-56, 2012.

Nourse, J.L., B. Ziaeian, T. Palmer, P.H. Schwartz, L.A. Flanagan.
Immunocytochemical analysis of human stem cells. In Human Stem Cell Manual: A Laboratory Guide, 2nd edition. J.F. Loring and S.E. Peterson, eds. Elsevier, 2012.

Labeed, F.H., J. Lu, H.J. Mulhall, S.A. Marchenko, K.F. Hoettges, L.C. Estrada, A.P. Lee, M.P. Hughes, L.A. Flanagan.
Biophysical characteristics reveal neural stem cell differentiation potential. PLoS ONE 6(9):e25458, 2011.

Wang, L., J. Lu, S.A. Marchenko, E.S. Monuki, L.A. Flanagan, A.P. Lee.
Dual frequency dielectrophoresis with interdigitated sidewall electrodes for microfluidic flow-through separation of beads and cells. Electrophoresis 30(5): 782-791, 2009.

Flanagan, L.A., J. Lu, L. Wang, S.A. Marchenko, N. Jeon, A.P. Lee, E.S. Monuki.
Unique dielectric properties distinguish stem cells and their differentiated progeny. Stem Cells 26(3): 656-665, 2008.

Ju, Y., P.A. Janmey, M.E. McCormick, E.S. Sawyer, L.A. Flanagan.
Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels. Biomaterials 28: 2097-2108, 2007.

Flanagan, L.A., L.M. Rebaza, S. Derzic, P.H. Schwartz, E.S. Monuki.
Regulation of human neural precursor cells by laminin and integrins. J. Neurosci. Res. 83(5): 845-856, 2006.

Chung, B., L.A. Flanagan, S. Rhee, P.H. Schwartz, A.P. Lee, E.S. Monuki, N. Jeon.
Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab on a Chip 5(4): 401-406, 2005.

Flanagan, L.A., Y. Ju, B. Marg, M. Osterfield, P.A. Janmey.
Neurite branching on deformable substrates. Neuroreport 13(18): 2411-5, 2002.

Contact Information

E-mail:

lflanaga@uci.edu

Phone:

949-824-5786

FAX:

949-824-0264

Address:

University of California, Irvine
845 Health Sciences Rd.
3030 Gross Hall
Mail Code: 1705
Irvine, CA 92697

The Lab

Jamison L. Nourse
Project Scientist
Ying Li
Masters Student
Adnan Akil
Masters Student
Adnan Akil
Lab Manager

Supporting This Work

Donations to labs may be applied in many ways: from costs for experiments to support for a student's stipend.

Join us in becoming a part of scientific history, by supporting the work of this lab.

Learn more by contacting Pamela Foster, pamela.foster@uci.edu, or by visiting our Get Involved Page, where you can donate online.